Frontline Plus, 45-88 lb
The traditional monthly spot-on — kills adult fleas plus eggs and larvae, and is waterproof 24 hours after application
FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3
This is something you buy again. We have not worked out a verified monthly cost for this one yet, and would rather say so than divide a pack price by a guess.
The variant we link: 45-88 lbs · PurpleOne Amazon page often holds several sizes; check the selected option before you buy.
Amazon links earn us a commission; it doesn’t change what we recommend. Researched, not tested — how we research.
Price checked November 1, 2026; the listing has today's price.
Most owners add · Grooming & Nails
Brushing is the check: it is how a tick gets found before it has been attached a day.
Suits these stages
Is the Frontline Plus, 45-88 lb right for your dog?
- Who it’s for
- The traditional monthly spot-on — kills adult fleas plus eggs and larvae, and is waterproof 24 hours after application.
- Who should skip it
- Your dog is outside the 45-88 lb band. Buy the pack for your dog's actual weight, never a split dose.
The verdict
The long-standing over-the-counter spot-on, and the reason it stays relevant is the second active ingredient: fipronil kills adult fleas, and (S)-methoprene targets eggs and larvae, which is the half of the population living in your carpet rather than on your dog. Frontline state it protects for a full month, kills adult fleas, flea eggs, flea larvae, ticks and chewing lice, and is waterproof 24 hours after application. This pack is banded for dogs of 45 to 88 pounds. Owner feedback is genuinely divided on effectiveness, which reflects real regional resistance patterns as much as anything — some areas have flea populations that respond poorly. If it is not working where you live, that is a specific and useful thing to tell your vet rather than a reason to double up.
Drawbacks
- Effectiveness reports vary by region — resistance is real
- Monthly application is easy to forget
WagScore
74out of 100- Owner satisfaction
- 71
- Stage fit
- 80
Owner satisfaction from the product's Amazon star rating and review count; stage fit from our own assessment of how well it suits a dog at puppy, adolescent, adult, senior stage.
What the listing says
- Targets eggs and larvae as well as adult fleas
- Waterproof 24 hours after application
- Widely available without a prescription
Specifications
- Protection Duration
- 1 month per dose (3-dose pack)
- Application Method
- Topical (spot-on)
- Dog Size
- 45–88 lbs
- Active Ingredients
- Fipronil, (S)-Methoprene
- Water Resistance
- Yes (after 24 hrs)
- Flea & Tick Kill
- Fleas, ticks, flea eggs & larvae
From the maker’s listing and Amazon’s product data. Fields the listing doesn’t state are left out, not assumed.
If this one isn’t right
Skip it if: Your dog is outside the 45-88 lb band. Buy the pack for your dog's actual weight, never a split dose.
Our top pick on this shelf, if you would rather start from what we recommend first.
Seresto 8-Month Flea & Tick Collar
$99.98
A dog-only household that wants one monthly spot-on against fleas, ticks and mosquitoes.
$57.42
← Back to the flea & tick comparisonNot sure what stage your dog is in? →
Gear
Pairs with
What tends to be needed alongside flea & tick — hand-picked adjacencies, not "customers also bought".
$35.27 Owner rating 4.7 out of 5 · 13,229
Brushing is the check: it is how a tick gets found before it has been attached a day.
$65.69 Owner rating 4.1 out of 5 · 1,247
The dogs that get ticks are the ones that get into long grass, which are the dogs that also get lost.
$45.99 Owner rating 4.5 out of 5 · 23,731
Peak tick season and peak heat season are the same months.
The rest of this shelf
Everything else we currently recommend on the flea & tick shelf — the same need, Protect.
